Erythrocyte Morphology And Its Disorders Discussion
Discussion post
Describe the morphology of erythrocytes, the mechanism, and the primary cause of the following anemias: Pernicious anemia, folate deficiency anemia, iron deficiency anemia, thalassemia, and sickle cell anemia.
Morphology of erythrocytes
According to Adewoyin et al. (2019), the most prevalent type of blood cell in humans is erythrocytes, also identified as red blood cells. They are nucleated biconcave discs that incorporate hemoglobin, a protein that binds to oxygen and transports it all over the body. Erythrocytes develop in the bone marrow and possess a lifespan of about 120 days.
The mechanism and primary cause of;
- Pernicious anemia
An autoimmune condition known as pernicious anemia is brought on by a lack of vitamin B12, essential for forming red blood cells. Lack of B12 forces erythrocytes to be damaged, which causes a shortage of red blood cells. Pernicious anemia has normal-sized and-shaped erythrocytes; however, there are fewer overall (Manchanda, 2019). Erythrocyte Morphology And Its Disorders Discussion
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- Folate deficiency anemia
Folate deficiency anemia is caused by a lack of folic acid, a B vitamin that forms erythrocytes. According to Manchanda (2019), Folate deficiency leads to the generation of larger-than-normal erythrocytes, known as megaloblastic anemia. The erythrocytes have an oval shape and a shorter life span.
- Iron deficiency anemia
Adewoyin et al. (2019) identify Iron deficiency anemia as the most prevalent type of anemia triggered by a shortage of iron, essential to creating hemoglobin. Lack of sufficient iron leads to the production of smaller erythrocytes and paler than normal. This is known as microcytic, hypochromic anemia.
- Thalassemia
Thalassemia is a genetic condition that impacts hemoglobin production, according to Manchanda (2019). Thalassemia produces erythrocytes that are anomalously shaped and have a shorter life expectancy. Thalassemia is classified into alpha and beta, and the kind and quantity of mutations present determine the intensity of the anemia.
- sickle cell anemia
Another hereditary condition that influences hemoglobin synthesis is sickle cell anemia. Compared to regular erythrocytes, sickle cell anemia erythrocytes are crescent-shaped and possess a shorter lifespan. These aberrant erythrocytes have the potential to obstruct blood flow, resulting in tissue injury and discomfort (Manchanda, 2019). Erythrocyte Morphology And Its Disorders Discussion
References
Adewoyin, A. S., Adeyemi, O., Davies, N. O., & Ogbenna, A. A. (2019). Erythrocyte morphology and its disorders. Erythrocyte, 1-10. https://cdn.intechopen.com/pdfs/67667.pdf
Manchanda, N. (2019). Anemias. Rodak’s Hematology-E-Book: Clinical Principles and Applications, 251
Discussion post
Describe the morphology of erythrocytes, the mechanism, and the primary cause of the following anemias: Pernicious anemia, folate deficiency anemia, iron deficiency anemia, thalassemia, and sickle cell anemia.
Morphology of erythrocytes
According to Adewoyin et al. (2019), the most prevalent type of blood cell in humans is erythrocytes, also identified as red blood cells. They are nucleated biconcave discs that incorporate hemoglobin, a protein that binds to oxygen and transports it all over the body. Erythrocytes develop in the bone marrow and possess a lifespan of about 120 days.
The mechanism and primary cause of;
- Pernicious anemia
An autoimmune condition known as pernicious anemia is brought on by a lack of vitamin B12, essential for forming red blood cells. Lack of B12 forces erythrocytes to be damaged, which causes a shortage of red blood cells. Pernicious anemia has normal-sized and-shaped erythrocytes; however, there are fewer overall (Manchanda, 2019).
- Folate deficiency anemia
Folate deficiency anemia is caused by a lack of folic acid, a B vitamin that forms erythrocytes. According to Manchanda (2019), Folate deficiency leads to the generation of larger-than-normal erythrocytes, known as megaloblastic anemia. The erythrocytes have an oval shape and a shorter life span. Erythrocyte Morphology And Its Disorders Discussion
- Iron deficiency anemia
Adewoyin et al. (2019) identify Iron deficiency anemia as the most prevalent type of anemia triggered by a shortage of iron, essential to creating hemoglobin. Lack of sufficient iron leads to the production of smaller erythrocytes and paler than normal. This is known as microcytic, hypochromic anemia.
- Thalassemia
Thalassemia is a genetic condition that impacts hemoglobin production, according to Manchanda (2019). Thalassemia produces erythrocytes that are anomalously shaped and have a shorter life expectancy. Thalassemia is classified into alpha and beta, and the kind and quantity of mutations present determine the intensity of the anemia.
- sickle cell anemia
Another hereditary condition that influences hemoglobin synthesis is sickle cell anemia. Compared to regular erythrocytes, sickle cell anemia erythrocytes are crescent-shaped and possess a shorter lifespan. These aberrant erythrocytes have the potential to obstruct blood flow, resulting in tissue injury and discomfort (Manchanda, 2019). Erythrocyte Morphology And Its Disorders Discussion
References
Adewoyin, A. S., Adeyemi, O., Davies, N. O., & Ogbenna, A. A. (2019). Erythrocyte morphology and its disorders. Erythrocyte, 1-10. https://cdn.intechopen.com/pdfs/67667.pdf
Manchanda, N. (2019). Anemias. Rodak’s Hematology-E-Book: Clinical Principles and Applications, 251. https://doi.org/10.4103%2Fjfmpc.jfmpc_2456_20 Erythrocyte Morphology And Its Disorders Discussion