Reviewing a Randomized Clinical Trial on Psilocybin Assignment
Study Description and Purpose
Article chosen is “Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial”, (Davis et al., 2020). The purpose of the study was to evaluate the efficacy of psilocybin-assisted therapy as a method for treating major depressive disorder (MDD). The study recruited 24 MDD patients who were randomly assigned to receive either psilocybin or a placebo along with supportive psychotherapy. It was a randomized clinical trial that was carried out at an academic medical center in the United States. The Hamilton Depression Rating Scale (HDRS), which rates the severity of depressive symptoms, served as the major outcome measure. Reviewing a Randomized Clinical Trial on Psilocybin Assignment
Results
The results of the study showed that participants who received psilocybin-assisted therapy saw significantly lower HDRS scores at both the one-week and three-month follow-up assessments than those who got the placebo. At the one-week follow-up, the effect size was significant (Cohen’s d = 2.2), and at the three-month follow-up, it was modest (Cohen’s d = 0.8).
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Discussion of Findings
The study’s findings point to psilocybin-assisted therapy as a potentially effective MDD treatment option. It is noteworthy that the substantial effect size seen during the one-week follow-up shows that the treatment may have quick and long-lasting benefits on depression symptoms. The limited sample size, lack of long-term follow-up, and lack of a direct comparison between psilocybin and currently available treatments for MDD are some of the study’s drawbacks, though.
Evaluation of Research Quality
I utilized the CAT (Critical Appraisal Tool) for Randomized Controlled Trials, which is accessible on the website supplied in the assignment instructions, to assess the caliber of the research. In order to evaluate the study’s methodological rigor, the CAT poses a series of inquiries about the study’s design, blinding, randomization, and data analysis. My assessment of the study using the CAT suggests that it was well planned and carried out, with adequate randomization techniques, blinding, and statistical analyses. Reviewing a Randomized Clinical Trial on Psilocybin Assignment
Implications for Practice
According to the study’s findings, psilocybin-assisted therapy may be used as a treatment option for MDD, especially for people who have not responded to standard therapies or who are looking for alternative methods of treatment (Sloshower et al., 2020). It is crucial to remember that this therapy approach is still relatively new and needs more investigation to determine its safety and effectiveness. Before suggesting or providing this medication to specific individuals, healthcare professionals should carefully weigh the potential risks and advantages of doing so.
In conclusion, psilocybin-assisted therapy may be a useful therapeutic option for major depressive illness, according to the research by Davis et al. (2020). The study seems to have been well planned and carried out using strict methodological methods. However, more study is needed to determine the long-term effectiveness and safety of this treatment as well as explore its potential application for other mental health issues. It’s also crucial to remember that psilocybin is a regulated substance and that using it is prohibited in many places. As a result, access to this medicine is now restricted and tightly controlled.
Overall, the results of this study look promising and imply that psilocybin-assisted therapy might provide a new and efficient method for treating MDD. However, healthcare professionals should proceed cautiously and thoroughly weigh the advantages and disadvantages of this treatment for specific patients (Cosci et al., 2020). The effectiveness and safety of this treatment, as well as its potential for widespread usage in clinical practice, still require more investigation. Reviewing a Randomized Clinical Trial on Psilocybin Assignment
References
Cosci, F., Mansueto, G., & Fava, G. A. (2020). Relapse prevention in recurrent major depressive disorder. A comparison of different treatment options based on clinical experience and a critical review of the literature. International Journal of Psychiatry in Clinical Practice, 24(4), 341-348.
https://www.tandfonline.com/doi/abs/10.1080/13651501.2020.1779308
Davis, A. K., Barrett, F. S., May, D. G., Cosimano, M. P., Sepeda, N. D., Johnson, M. W., … & Griffiths, R. R. (2021). Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial. JAMA psychiatry, 78(5), 481-489.
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2772630
Sloshower, J., Guss, J., Krause, R., Wallace, R. M., Williams, M. T., Reed, S., & Skinta, M. D. (2020). Psilocybin-assisted therapy of major depressive disorder using acceptance and commitment therapy as a therapeutic frame. Journal of Contextual Behavioral Science, 15, 12-19.
https://www.sciencedirect.com/science/article/pii/S2212144719301218
Carefully consider the topic listed below:
Hallucinogenic therapy Reviewing a Randomized Clinical Trial on Psilocybin Assignment
This treatment modality is relatively new to the psychiatric treatment realm. It is important to consider the pros and cons of each therapeutic modality as well as its applicability to certain groups of patients before making a decision regarding its applicability in your practice. Â
The purpose of this assignment is to identify research that has been done with one or more of these modalities and determine the quality of the research.Â
Locate one article describing research with one or more of these modalities as a form of treatment for a group of selected patients. (I have included 2 articles, select whichever ONE is most appropriate after evaluating it).
Answer the following questions following your review of the research article.
* Describe the study and its purpose.
* Describe the results of the study.
* Discuss whether you found the results of the study to be helpful.
* Based on the findings in this study, would you consider this as a treatment modality? Why? or Why not?
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In order to determine the quality of the research, which can affect the outcomes and the feasibility of the study, refer to this website:
https://www.unisa.edu.au/research/allied-health-evidence/resources/cat/
This website has a selection of tools that fits the type of article you have chosen to review. If the article does not fit into one of the categories, you may not have a research article.Â
Include a copy of the article and the tool you used to evaluate the article with your review and upload all these documents to the assessment area.Â
***Please upload the article, the completed review instrument and your review as separate documents to the assignment area clearly labeled so they can easily be located for grading.*** Reviewing a Randomized Clinical Trial on Psilocybin Assignment